Hyperemesis Gravidarum Medication Update

I had an appointment with my doctor this morning.  I was very pitiful.  The hyperemesis gravidarum has kicked in and I was pretty sad.  I am feeling like utter crap.  I’m trying to avoid the F-bomb here because I know my mom reads this, but that’s the way I’ve been feeling lately.  Horrible.

My doctor went ahead upped my zofran dosage to the full 32 mg.  Since I don’t want to wake my carcass up at night to take it, she suggested doing every 4 hours.  That’s bunching it up a lot, but that’s okay.

One thing to be aware of with high doses of Zofran is constipation. Severe, severe constipation. When you’re taking it, you’ve got to be prepared to deal with that whether it’s through fiber pills, stuff like senekot, or enemas. *shudder* It sucks, but it’s the reality of Zofran use.

She also had me add in benadryl to see if that helps with the nausea.  We talked a bit about fluids.  Since I’m able to drink still, she doesn’t want to make me a pincushion just yet.  She did say to not worry so much about eating solids and mostly just worry about fluids.

So I’m worrying about fluids.  Thankfully there is a Jamba Juice a few blocks from my house.  I can still drink those.  There’s one called the Protein Berry Workout that is working out fine for me at the moment.  I have them put whey protein in there along with fiber and a daily vitamin.  So far so good.

We also talked very briefly about medical marijuana, something that is legal in California and does seem to help women with hyperemesis gravidarum.  I haven’t made up my mind on this yet, and I may or may not post about it if I do.  I don’t smoke pot, and I have no interest in smoking it, but if there is something there that might help then it may be worth at least thinking about.

She also wrote me off of work completely until April.

25 thoughts on “Hyperemesis Gravidarum Medication Update

  1. Believe it or not, thanks for this post. I wish I had that information when I was on Zofran. I sort of heard of the enema thing, never tried it. Was in pain. and didn’t realize how serious it can be if you don’t get things moving. I use to force coffee down my throat.
    how are you able to walk into a jamba juice with all the smells?


  2. I’ve wondered about marijuana to treat HG for a while now. I might consider trying it. My justification for this is, I’ve put so many other “legal” and powerful drugs in my body, so why would marijuana be any different. We’re not worried about taking Zofran, so why does pot scare us? Yes, there are side effects for the baby but that is possible with all the other meds we take too. I think it would be a great way for us to increase our appetite at a time when we are not able to put anything into our bodies.

    Let me know if you do try it!


    1. Definitely try pot. Like you said above you aren’t worried about talking these chemical pills for relief, why not try something natural. Pot does help with nausea. It helps a lot! If anyone doesn’t want to take chemicals for nausea pot is wonderful at taking a way nausea. If you’re not use to it I would say smoke, eat whatever pot at night.


      1. I feel like I should add a statement that says that I would advise all of my readers to consult with their doctors AND ensure they follow state laws and regulations with regard to this. 🙂


  3. Yay for the enema working! I never ended up trying it either…wasn’t sure if it would work too well. Good to have a brand to try for next time too. I would def love to know if marijuana works for you if you try it. Thanks for keeping it real!


  4. The medical marijuana comes in edible forms, which I realize may not work for you. There are also atomizers that’ll release the mj as steam
    (not smoke) that you can inhale. I have friends who use medical mj, I can put you in contact with them if you have questions.


  5. 1) “Bottom line,” hehehe.
    2) Yeah, it’s not the least squirm-worthy moment when purchasing disposable enemas. It reminds me of that commercial where the guy is buying wart remover and of course the automated check-out machine malfunctions and keep repeating “Wart remover. Wart remover. Wart. Wart. Wart. Wart.”
    3) I was also wondering about the feasibility of medical marijuana. Rather than smoking, I wonder if it would be more or less disturbing to manufacture it into food. While I’ve never played with it, from what I understand it bonds with alcohol or butter–the second being the more pregnancy-friendly option, as long as food made with butter is compatible with your dietary concerns. But easy enough to prepare and possibly less irritating than trying to smoke it, which I’d fear could trigger gagging. I for one would be really interested in your update on this front.


  6. I think your post was great! You are keppi g it real and I am sure that’s totally helping others.
    I have heard the medical marijuana is great for curbing nausea and helps increase appetite, might be something to try! I think the pp has good advice about perhaps adding it to your food. No matter what you decide, I hope you get to feeling some relief.


  7. So glad you’re feeling at least a little better.

    About the medical herb…I most definitely would have tried it if I thought it would make things better during my pregnancies. The food thing probably won’t work for anyone who cannot keep food down. Which is so many of us. I think vaporizer would have been my first choice.

    I try to stay up to date on anything that might help…just in case my daughter finds herself in the same shoes some day.

    Hang in there, little momma.


  8. Molly,

    Thank you for touching on this subject!!! I ended up in the hospital for lengthy periods of time (we’re talking weeks, like, I watched the presidential election from a hospital bed), several times (I think three?) because of fecal impactions. They were worried I could have some kind of severe intestinal blockage. I would go in, be pumped full of a constant IV drip of just liquids, then take Milk of Magnesia every 4 hours or so, Colace, Pepcid, and several laxatives. It was so sad. Worst pain I’ve ever ever ever been in, still to date. Nothing topped that pain I woke up with one morning when I had a bad impaction. I was doubled over. I won’t get into it, but it was like a charlie horse in my stomach. Ugh. All because of Zofran. I wish I’d known. All the nurses were completely baffled, saying they’d never seen anyone with this side effect before. But my research shows that it’s extremely common, so I don’t know what they were talking about. It was awful and humiliating to be the joke on the Antipartum floor, “Room 321 is here because she can’t poop…” I could hear them at shift change over in the hall. Ugh.


  9. Kathleen- that is so NOT ok! I am sorry that you had to deal with that. It is very serious and I don’t even know one woman who doesn’t have that side effect with Zofran. Although no one told me about that side effect, I quickly figured it out after a week. And then I was so afraid to take colace, despite all the other drugs I was taking. That was always my biggest hurdle (and sometimes still is) I don’t like to take any medicines and then when you have HG you find yourself in a position of having to take them, and the worry involved. But it is safe and it seems Mr. Fleet is safe, and these are lifesavers! Not a joke.


  10. I didn’t really notice this problem, because I never ate. I figured that being on TPN meant you didn’t poop. I mean, what would you poop out? Nothing goes through the digestive tract via hyperalimentation. But somewhere around that magical 20 weeks I had a sweet little rabbit pellet left over from actually using the digestive process to metabolize nutrition months earlier, and that sucker was like birthing a semi. Maybe that was due to the Zofran or just the TPN-Gut dormancy duo. I was able to drink an aforementioned drink that sent Pal over the edge even when she was still eating fairly well. That and M.O.M. And out popped an M&M you could have loaded a gun with. HG is so glamorous!


  11. I’m not seeing your usual Sunday post, so I’m thinking it might have been a rough day for you. You’ve been on my mind all day- and in my prayers! Hang in there!


  12. oh man. I remember the constipation. And when I told my OB I thought it was from the Zofran he looked at me funny and said, I’d never heard of that.

    Hang in there Momma! You can do this!!!


  13. Yeah, I remember this awful problem during my second pregnancy. Finally after 12 days of not going, I broke down and let my husband buy the enema. It worked and I wished I would have done it sooner to avoid the pain of constipation.


  14. I love your blog. Thank you for writing this, it gives me comfort. I am suffering from horrible HG now, I am 16 weeks pregnant and have been deathly sick since week 4. I am on the zofran pump and have been struggling with constipation since last month. Poop doesn’t embarrass me anymore, haha. I have tried an emema, mineral oil emema, with no luck! It devastated me bc I need to go so terribly. I was wondering what exact type of emema you used?

    I have tried Miralax, Benefiber, Dulcolax, suppositories, etc. No luck:(

    Thanks so much!!


  15. Oh MY GOODNESS! so THAT’s why I’ve been so constipated!! I’ve been getting migraines from zofran, but didn’t even KNOW about this. And it’s been HELL. thanks for sharing!

    I must admit that for the last ten weeks I’ve been popping dried fruit like candy, absolutely whenever I COULD eat. But I’ve stopped in the last two weeks and the constipation has been unreal. Now I understand! Thanks thanks thanks!


    1. Yes! It is definitely the Zofran (ondansetron)! That stuff keeps everything in. Just wait until you’re eating enough to move on from dried fruit to golf balls. *shudder* That’s been me since I started back on the ODT tablets. The pump was a lot less harsh on the old lower intestine for some reason.


  16. This is quite an old post but I’m commenting anyway to say thanks. So obviously I can’t get pregnant (something about not having testicles instead of ovaries?) and I have never experienced HG. When I was going through chemo in 2012 they gave me Reglan for nausea, which caused quite the opposite side effect that Zofran does. Thankfully at that time my weird diet helped to combat it.

    Fast forward a year and a half after I fi finished chemo. I still deal with quite a few side-effects, nausea being one of then. A recent trip to the ER for extreme stomach cramping and some swelling near the groin led me to finding out I have an inguinal hernia. They said it would cause the nausea I am having recently and gave me Zofran. I’ve taken it for 2 days now, 3 times a day. I haven’t gine two days without nausea in over a year. But now, I haven’t gone in two days either.

    A quick search to see if there was a relation between the two led me here. Obviously my suspicions are correct. And now I know what I may want to try instead of taking more meds. (Not a big fan of taking meds unless absolutely necessary).

    So thanks for sharing about your poo. Bet you never thought you would hear those words 🙂


    1. Ouch, I’m so sorry you struggled with nausea so much. Zofran can be a lifesaver, but the side effect is brutal. Not sure how it effects an inguinal hernia, but constipation plus hernia cannot be good. Yikes.


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